Synthesis and characterization of novel triazol compounds containing a thiophen ring as potential antifungal agents and the structure of 2-(2-hydroxy-2-p-tolyethyl)-5-(thiophen-2-ylmethyl)-4- (4H-1,2,4-triazol-4-yl)-2H-1,2,4-triazol-3(4H)-one

Authors : Yasemin ÜNVER, Esra DÜĞDÜ, Kemal SANCAK

Pages : 551-564

View : 20 | Download : 11

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of new 4-insert ignore into journalissuearticles values(3,5-disubstitue-4H-1,2,4-triazol-4-yl);- 5-insert ignore into journalissuearticles values(thiophen-2-yl-methyl);-2H-1,2,4-triazol-3insert ignore into journalissuearticles values(4H);-ones insert ignore into journalissuearticles values(3a-c); were obtained by reaction N`-1-ethoxy-2-thiophen-2-yl-ethylydene hydrazino carboxylic acid ethyl ester insert ignore into journalissuearticles values(1); and 4-amino-4H-1,2,4-triazoles insert ignore into journalissuearticles values(2);. 4-insert ignore into journalissuearticles values(3,5-disubstitue-4H-1,2,4-triazol-4-yl);-2-insert ignore into journalissuearticles values(2-oxo-2-arylethyl);-5- insert ignore into journalissuearticles values(thiophen-2-yl-methyl);-2H-1,2,4-triazol-3insert ignore into journalissuearticles values(4H);-ones insert ignore into journalissuearticles values(4a-e); and ethyl 2-insert ignore into journalissuearticles values(4-insert ignore into journalissuearticles values(3,5-disubstitue-4H-1,2,4-triazol-4-yl);-5-oxo-3-insert ignore into journalissuearticles values(thiophen-2-ylmethyl);- 4,5-dihydro-1,2,4-triazol-1-yl);acetates insert ignore into journalissuearticles values(6a-c); were obtained by reaction of compounds 3 and bromoacetophenon derivatives and bromo ethylacetate, respectively. Compounds 5a-e were synthesized from the reaction of corresponding compounds 4a-e with NaBH4. Compounds 7a-c were obtained by the reaction compounds 6 and LiAlH4. Seventeen new compounds were synthesized and characterized by elemental analyses, IR, 1H-NMR, and 13C-NMR spectral data. The structure of compound 5d was inferred through IR, 1H-, 13C-NMR, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antibacterial and antifungal properties. Among the chemicals tested, 6a and 6b exhibited the highest degree of antifungal activity.
Keywords : Synthesis, 1, 2, 4 triazole 3 one, NaBH4, LiAlH4, antimicrobial activity, X ray