A simple and efficient procedure for synthesis of optically active 1,3,4-oxadiazole derivatives containing L-amino acid moieties

Authors : Naser FOROUGHIFAR, Akbar Mobinikhaledi And Sattar EBRAHIMI, Sattar EBRAHIMI

Pages : 603-611

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some new unsymmetrical and optically active 2,5-disubstituted 1,3,4-oxadiazoles 5a-j were efficiently synthesized by cyclization reaction of diacylhydrazides 4a-j. The synthesis of the title compounds was achieved by the reaction of acyl hydrazides 3a-b and N-phetaloyl-L-amino acids 1a-e in the presence of the phosphoroxy chloride insert ignore into journalissuearticles values(POCl3); as an anhydrous reagent.
Keywords : N phetaloyl L amino acid, 1, 3, 4 oxadiazole, diacylhydrazide, pyridoyl hydrazide, phosphoroxy chloride