Synthesis, characterisation, and structural elucidation by spectral investigation (FT-IR, multinuclear NMR, mass spectrometry) of biologically active organotin(IV) compounds containing germanium

Authors : Muhammad Kaleem KHOSA, Muhammad MAZHAR, Saqib ALI

Pages : 387-398

View : 17 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new series of di and tri-organotininsert ignore into journalissuearticles values(IV); compounds containing germanium with the general formula R4-nSnLn was synthesised by reaction of 3-triphenylgermanyl-3,3-dimethylpropionic acid with organotininsert ignore into journalissuearticles values(IV); oxides and organotininsert ignore into journalissuearticles values(IV); chloride in 2:1 and 1:1 molar ratio, respectively, where R~=~CH3, C2H5, n-C4H9, n-C8H17, and C6H5 n = 1 or 2 and L~=~triphenylgermanyl acid anion insert ignore into journalissuearticles values(GeC23 H23 O2-);. These compounds were characterised by elemental analyses, FT-IR, multinuclear NMR insert ignore into journalissuearticles values(1H, 13C, 119Sn);, and mass spectrometry. The geometry around the tin atom was determined and compared in both solution and solid states. The spectroscopic results indicated that all the diorganotininsert ignore into journalissuearticles values(IV); compounds containing germanium possess trigonal-bipyramidal structures in solution and octahedral geometry in the solid state. A linear polymeric trigonal-bipyramidal structure in the solid state and a tetrahedral environment around the tin atom in non-coordinating solvents has been proposed for the triorganotininsert ignore into journalissuearticles values(IV); compounds. All synthesised compounds were tested in vitro against a number of microorganisms to assess their biocidal properties and to correlate them with the structures of the derivatives. These studies revealed that such compounds show promising activity against different strains of bacteria and fungi using the reference drugs imipenum and miconazole.
Keywords : Bimetallic organotin, germanium carboxylates, microbibial activity