Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity

Authors : Synthesis Of Some New Biheterocyclic Tri AND

Pages : 165-180

Doi:10.3906/sag-1208-2

View : 15 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :2-{3-insert ignore into journalissuearticles values(4-Substitutedbenzyl);-4-[2-insert ignore into journalissuearticles values(1H-indol-3-yl);ethyl]-5-oxo-4,5- dihydro-1H-1,2,4-triazol-1-yl}-N`-insert ignore into journalissuearticles values(aryl-methylene);acetohydrazides insert ignore into journalissuearticles values(5a-g);, 4-amino-2-{-insert ignore into journalissuearticles values(4-substitutedbenzyl);-5-oxo-4,5-dihydro-1H-1,2,4-triazol- 1-yl}-N`-insert ignore into journalissuearticles values(arylmethylene);acetohydrazides insert ignore into journalissuearticles values(6a,b);, and 4-[2-insert ignore into journalissuearticles values(1H-indol- 3-yl);ethyl]-5-insert ignore into journalissuearticles values(4-substitutedbenzyl);-2-{5-insert ignore into journalissuearticles values(phenylamino);-1,3,4-thiadiazol- 2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-ones insert ignore into journalissuearticles values(8a,b); were synthesized starting from 4-alkyl-5-insert ignore into journalissuearticles values(4-substitutedbenzyl);-2,4-dihydro- 3H-1,2,4-triazol-3-ones insert ignore into journalissuearticles values(2a-c); by several steps and their structures were well characterized by elemental analyses, IR, 1H-NMR, 13C-NMR, and mass spectral studies. They were also screened for their microbial activities. The obtained antimicrobial activity results revealed that 12 among the 24 compounds tested displayed variable growth inhibition effects on the tested gram-positive and gram-negative bacterial strains. None of the compounds showed antifungal activity against yeast-like fungi.
Keywords : 1, 2, 4 Triazole, 1H indole, 1, 3, 4 thiadiazole, Schiff base, antimicrobial activity