Synthesis, structural determination, and biological activity of new 7-hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their o-b-D-glucosides

Authors : Structural Determination, And biological activity of New

Pages : 241-254

Doi:10.3906/sag-1206-30

View : 21 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A convenient route to synthesize some new medicinally important 7-hydroxy-3-pyrazolyl chromones insert ignore into journalissuearticles values(3a-i); is described. The interaction of 7-hydroxy-3-formyl chromone insert ignore into journalissuearticles values(1); with various substituted acetophenones and further cyclization with hydrazine hydrate in an aprotic solvent followed by condensation with 2, 3, 4, 6-tetra-o-acetyl-a-dglucopyranosyl bromide afforded 2, 3, 4, 6-tetra-o-acetyl-b-d-glucopyranosyloxy-3-insert ignore into journalissuearticles values(3-aryl-1H-pyrazol-5- yl);-4H-chromen-4-ones insert ignore into journalissuearticles values(4a-i);. Later deacetylation with anhydrous zinc acetate in methanol gave 7-o-b-d-glucopyranosyloxy-3-insert ignore into journalissuearticles values(3-aryl- 1H-pyrazol-5-yl);-4H-chromen-4-ones insert ignore into journalissuearticles values(5a-i);. These compounds were evaluated for their in vitro antimicrobial and anti-oxidant activity. The structures of these newly synthesized o-glucosides were established by IR, NMR, mass spectra, elemental analysis, and chemical analysis.
Keywords : Chromones, pyrazoles, glucopyranosyl bromide, glucosylation, o b d glucosides