Inclusion and release of theophylline from chitosan based microparticles

Authors : Inclusion and release of theophylline fr Microparticles

Pages : 255-262

Doi:10.3906/sag-1204-23

View : 22 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Chitosan insert ignore into journalissuearticles values(CS); based microparticles for controlled release of theophylline insert ignore into journalissuearticles values(THP); were obtained by ionic gelation. The microparticles were characterized by laser diffraction analysis insert ignore into journalissuearticles values(particle size);, scanning electron microscopy insert ignore into journalissuearticles values(SEM);, FTIR spectroscopy, and thermogravimetric analysis. The average diameter of the CS-THP microparticles was 182 m m. The FTIR spectra confirmed that new hydrogen bonds had formed between the carbonylic group belonging to THP and the amino group of CS, while the thermogravimetric analysis showed a modified stability in the obtained particles and confirmed the presence of an interaction between the drug and CS. The THP release process was monitored for up to 24 h in simulated gastric fluid insert ignore into journalissuearticles values(pH 1.5); and in simulated intestinal fluid insert ignore into journalissuearticles values(pH 7.4);. The release process of THP from microparticles was not influenced by the pH of dissolution media. In the first 30 min the drug was released in a rapid manner, and after this stage by a non-Fickian profile.
Keywords : Chitosan, theophylline, microparticles, controlled drug release