Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Authors : Mahla TABESHNIA, Hossein HELI, Ali JABBARI

Pages : 35-46

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The electro-oxidation of mefenamic acid, diclofenac, and indomethacin on glassy carbon and alumina nanoparticle-modified glassy carbon electrodes in a phosphate buffer solution at physiological pH was studied. The techniques of cyclic voltammetry, chronoamperometry, impedance spectroscopy, and steady state polarization measurements were applied. The drugs were irreversibly oxidized on bath electrodes via an anodic peak and the process was controlled by diffusion in the bulk of solution. Alumina nanoparticles increased the oxidation current, and lowered the peak and onset potentials. As such, alumina nanoparticles had an electrocatalytic effect, both kinetically and thermodynamically. The kinetic parameters of heterogeneous electron transfer and diffusion coefficients of the drugs are reported.
Keywords : Modified electrode, alumina nanoparticle, electrocatalysis, mefenamic acid, diclofenac, indomethacin