Antioxidant and anticholinesterase constituents of Salvia poculata

Authors : Ufuk KOLAK, Işıl HACIBEKİROĞLU, Mehmet ÖZTÜRK, Fevzi ÖZGÖKÇE, Gülaçtı TOPÇU, Ayhan ULUBELEN

Pages : 813-823

Doi:10.3906/sag-1205-29

View : 16 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Two triterpenoids, namely 2a,3a-dihydroxy-24-nor- 4insert ignore into journalissuearticles values(23);,12-oleanadien-28-oic acid insert ignore into journalissuearticles values(1); and ursolic acid insert ignore into journalissuearticles values(2);; 4 flavonoids, namely 5-hydroxy-7,4`-dimethoxyflavone insert ignore into journalissuearticles values(3);, cirsimaritin insert ignore into journalissuearticles values(4);, eupatilin insert ignore into journalissuearticles values(5);, and salvigenin insert ignore into journalissuearticles values(6);; a diterpenoid, namely sclareol insert ignore into journalissuearticles values(7);; and a steroid, namely b-sitosterol insert ignore into journalissuearticles values(8);, were isolated from the aerial parts of Salvia poculata Nab., a Turkish endemic Salvia species. Total phenolic and flavonoid contents of the crude extract were determined as pyrocatechol and quercetin equivalents, respectively. The antioxidant activity of the crude extract and the isolated compounds insert ignore into journalissuearticles values(2-8); was established using b-carotene bleaching, superoxide anion radical, and ABTS cation radical scavenging activity. In addition, the anticholinesterase activity of the crude extract and the isolated compounds insert ignore into journalissuearticles values(2-8); against the enzymes acetylcholinesterase insert ignore into journalissuearticles values(AChE); and butyrylcholinesterase insert ignore into journalissuearticles values(BChE); was determined. The phytochemistry and antioxidant and anticholinesterase activities of S. poculata were investigated for the first time in this study. The crude extract of S. poculata exhibited a significant antioxidant effect as well as butyrylcholinesterase inhibitory activity. Ursolic acid insert ignore into journalissuearticles values(2); and cirsimaritin insert ignore into journalissuearticles values(4); possessed high butyrylcholinesterase inhibitory activity.
Keywords : Salvia poculata, Lamiaceae, antioxidant activity, anticholinesterase activity