Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Authors : AbdelGalil ElSayed AMR, Naglaa AbdelSamei ABDELHAFEZ, Salwa Fahem MOHAMED, Mohamed Mostafa ABDALLA

Pages : 421-432

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide\textregistered and Lidocaine\textregistered as positive antiarrhythmic controls.
Keywords : Pyrimidine, pyrimidinethione, thiazolopyrimidine, antiarrhythmic activity