Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides

Authors : Vijay TAILE, Kishor HATZADE, Pravin Gaidhane And Vishwas INGLE

Pages : 295-305

View : 16 | Download : 13

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The 4-insert ignore into journalissuearticles values(4-hydroxybenzylidene);-2-methyl oxazol-5-ones 1 were treated with various aldehydes in the presence of acetic acid to form 4-insert ignore into journalissuearticles values(4-hydroxybenzylidene);-2-insert ignore into journalissuearticles values(substituted styryl); oxazol-5-ones 2a-i, which were glucosylated using a-acetobromoglucose as a glucosyl donor to afford 4-insert ignore into journalissuearticles values(4-o-b-d-tetra-o-acetyl-glucoxybenzylidene);-2- insert ignore into journalissuearticles values(substituted styryl); oxazol-5-ones 3a-i, which were deacetylated using zinc acetate in absolute methanol to form 4-insert ignore into journalissuearticles values(4-o-b-d-glucoxybenzylidene);- 2-insert ignore into journalissuearticles values(substituted styryl); oxazol-5-ones 4a-i. The compounds showed good antimicrobial and antifungal activity.
Keywords : Oxazolone, a acetobromoglucose, decetylation, o glucosides, antimicrobial and antifungal activity