Synthesis and Leishmanicidal Evaluation of Novel 4-Substituted-2,2-Dimethyl-7-(prop-2-ynyloxy)Chromenes

Authors : Babak H ALIZADEH, Alireza FOROUMADI, Sussan K ARDESTANI

Pages : 47-58

View : 18 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Substituted 4-chromenes were synthesized via the Grignard coupling reaction of various substituted phenyl- and benzylmagnesium chlorides with 2,2-dimethyl-7-insert ignore into journalissuearticles values(prop-2-ynyloxy);chroman-4-one insert ignore into journalissuearticles values(1); in relatively good yield insert ignore into journalissuearticles values(60%-85%);. The benzylic-substituted derivatives were a mixture of 2 exo and endo regioisomers, and the exo compounds were a mixture of E and Z isomers. Structural analysis of the exo and endo isomers, as well as E and Z of exo isomers were based on H-NMR, 13C-NMR, and NOESY experiments. The synthetic compounds were examined for in vitro activity against Leishmania major and compound 9 insert ignore into journalissuearticles values(a, b); was the most active, with inhibitory activity of 36%.
Keywords : Synthesis, chromene, leishmanicidal activity