Nitric Oxide Releasing Derivatives of [(2-Chloroethyl)ureido] Benzoic Acid Esters as Potential Antineoplastic Agents

Authors : Hülya AKGÜN, Barkın BERK, Dilek Demir EROL

Pages : 107-121

View : 22 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :New series of [insert ignore into journalissuearticles values(2-chloroethyl);ureido] benzoic acids insert ignore into journalissuearticles values(compounds 3-8); and nitric oxide releasing derivatives of [insert ignore into journalissuearticles values(2-chloroethyl);ureido] benzoic acid esters insert ignore into journalissuearticles values(compounds 9-14); were synthesized as potential anti-cancer agents. These compounds were screened for their anti-proliferative activities on A549 insert ignore into journalissuearticles values(human lung carcinoma); cells and for their cytotoxic effects on L929 insert ignore into journalissuearticles values(mouse fibroblast); cells. The compounds 3-8 exhibited mild cytotoxic effects on L929 cells insert ignore into journalissuearticles values(cell viability from 100% to 85% -- 90% only); whereas they had very little anti-proliferative activities towards A549 lung carcinoma cells. On the other hand, compounds 10, 11, and 13 had some growth inhibition activity in A549 insert ignore into journalissuearticles values(human lung carcinoma); cells. Among them, compounds 11 and 13 exhibited better anti-proliferative activities towards A549 cells, but also appeared to be cytotoxic towards L929 cells. In this group, the compound 10 with insert ignore into journalissuearticles values(1-insert ignore into journalissuearticles values(2-nitrooxyethyl);-3-[insert ignore into journalissuearticles values(2-chloroethyl);ureido]benzoate); structure appeared to have very weak anti-neoplastic activity towards A549 cells, with very little cytotoxic activity towards fibroblasts at physiological concentrations. Therefore, this compound is a better candidate for a potential anti-cancer therapy for non-small cell lung carcinomas. However, further studies are required in order to show applicability and effectiveness in animal models for this type of cancer.
Keywords : Nitric oxide, anti cancer agent, arylchloroethylureas