Production of (S)-(-)-1-(1´-Napthyl) Ethanol by Rhodotorula glutinis Isolate Using Ram Horn Peptone

Authors : Esabi B KURBANOĞLU, Kani ZİLBEYAZ, Namudar I KURBANOĞLU

Pages : 685-692

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The bioreduction of 1-acetonaphthone 1 by locally isolated Rhodotorula glutinis strains using ram horn peptone insert ignore into journalissuearticles values(RHP); gave insert ignore into journalissuearticles values(S);-insert ignore into journalissuearticles values(-);-1-insert ignore into journalissuearticles values(1´-naphthyl); ethanol insert ignore into journalissuearticles values(2);, an important pharmaceutical intermediate. R. glutinis strains were isolated from the water of fermented Salix leaves. Optimum fermentation conditions for the production of 2 were 200 rpm, 32 °C, and pH 6.5. The production of 2 with excellent enantiomeric excess insert ignore into journalissuearticles values(>99%);, and good conversion insert ignore into journalissuearticles values(100%); and yield insert ignore into journalissuearticles values(78%); under optimum conditions was achieved up to preparative scale via a fermenter. Wide temperature, pH, time, and agitation ranges did not affect the enantiomeric excess insert ignore into journalissuearticles values(ee); of the bioreduction product. A simple process for the isolation of R. glutinis was also developed.
Keywords : Acetonapthone, bioreduction, microbial reduction, asymmetric reduction