Synthesis and Antimicrobial Activities of 1,2,4-Oxadiazin-5-one, 6-one and 5-Thiones

Authors : Nevin ARIKAN, Doğan SÜMENGEN and Başaran DÜLGER

Pages : 147-155

View : 17 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :N-Substituted pyridine carboxamide oximes insert ignore into journalissuearticles values(2); were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides insert ignore into journalissuearticles values(1); with primary amines. The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-ones insert ignore into journalissuearticles values(3);, which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones insert ignore into journalissuearticles values(4);. The reaction of pyridine carboxamide oximes with a-aminoacid ester led to the formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones insert ignore into journalissuearticles values(5); in moderate yields. The structures of the prepared compound were evaluated by spectroscopy. Some of the representatives of 3,4-disubstituted-1,2,4- oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones were screened for antibacterial activity using disc diffusion. It was found that all the tested compounds have good antimicrobial activities.
Keywords : Amidoxime, oxadiazine, antimicrobial activity