A New Approach to Furan-Containing Macrolactones

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

Turkish Journal of Chemistry
Volume:31 Issue:3
A New Approach to Furan-Containing Macrolactones

A New Approach to Furan-Containing Macrolactones

Authors : Christoph Q SCHMIDT, Ruth MESSMER, Franz BRACHER, Jürgen KRAUSS

Pages : 251-256

View : 16 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Furan and tetrahydrofuran heterocycles are part of many natural products, like the Galerucella pheromone, furano epothilones, bipinnatin, and amphidinolides. This paper describes a short and efficient synthetic approach to furan-containing macrolactones in 4 steps, including as key steps a Sonogashira reaction and an olefin metathesis. The resulting compounds were tested at the National Cancer Institute for their cytotoxicity, but did not exhibit significant cytotoxicity in the human tumour cell line screen.
Keywords : Sonogashira reaction, Mitsunobu reaction, metathesis, cytotoxicity

ORIGINAL ARTICLE URL

VIEW PAPER (PDF)

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.