Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Authors : Yasemin DÜNDAR, Bilge ÇAKIR, Esra KÜPELİ

Pages : 301-313

View : 16 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :We synthesized new 1-[3-insert ignore into journalissuearticles values(2-oxobenzothiazolin-3-yl);propanoyl]-4- substituted-thiosemicarbazides and their corresponding cyclized 3-[2-insert ignore into journalissuearticles values(2-oxobenzothiazoline-3-yl);ethyl]-4-substituted-1,2,4-triazol-5-thione ana-logs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds.
Keywords : 2 Benzothiazolinone, thiosemicarbazide, 1, 2, 4 triazol 5 thione, analgesic and anti inflammatory activity