Synthesis and Antimicrobial Activities of Some New 1,2,4-Triazole Derivatives

Authors : Nurhan GÜMRÜKÇÜOĞLU, Mevlut SERDAR, Elif ÇELİK

Pages : 335-348

View : 22 | Download : 11

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of acylhydrazones insert ignore into journalissuearticles values(2a-f); were synthesized by the condensation of iminoester hydrochlorides insert ignore into journalissuearticles values(1a-f); with acyl hydrazines. 2,5-Dialkyl 1,3,4-oxadiazoles insert ignore into journalissuearticles values(3a,c,e); were obtained in the same reaction media. The treatment of acylhydrazones with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazoles insert ignore into journalissuearticles values(4a-c);. The acetylation of 4-amino-3,5-dialkyl-1,2,4-triazoles produced N-[3,5-dialkyl-4H-1,2,4-triazol-4-yl] acetamides insert ignore into journalissuearticles values(5-7);. The treatment of compounds 4a and 4c with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3,5-dialkyl-1,2,4-triazoles insert ignore into journalissuearticles values(8a,d, e, and 10a-e);. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl-1,2,4-triazoles insert ignore into journalissuearticles values(9a,d, e, and 11a-e);. Compounds 4b, 4c, 7, 8d, and 11c showed good antifungal activity only against yeast-like fungi, while compounds 3e, 6, 8e, and 9e showed antimicrobial activity against bacteria and yeast-like fungi.
Keywords : Acyl hydrazone, 1, 2, 4 triazole, 1, 3, 4 oxadiazole, Schiff Base, reduction, acetylation, antimicrobial activity