Synthesis, Spectroscopic Investigation, Crystal Structure, and Biological Screening, Including Antitumor Activity, of Organotin(IV) Derivatives of Piperonylic Acid

Authors : Muhammad HANIF, Mukhtiar HUSSAIN, Saqib ALI, Moazzam H BHATTI

Pages : 349-361

View : 25 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :We prepared 8 new organotin compounds with the general formulae [R3SnL], where R = Me insert ignore into journalissuearticles values(1);, Bu insert ignore into journalissuearticles values(2);, Ph insert ignore into journalissuearticles values(3);, and Cy insert ignore into journalissuearticles values(4); and [R2SnL2], where R = Me insert ignore into journalissuearticles values(5);, Et insert ignore into journalissuearticles values(6);, Bu insert ignore into journalissuearticles values(7);, Oct insert ignore into journalissuearticles values(8);, and L = piperonylic acid, and characterized them by elemental analyses, IR spectra, and multinuclear NMR insert ignore into journalissuearticles values(1H, 13C, and 119Sn);. The structure of 5 was confirmed by single crystal X-ray crystallography. The geometry around the tin atom was compared in both solution and solid state. Crystals of 5 are monoclinic with the space group P21/c. The tin geometry is skew trapezoidal bipyramidal, with 2 longer and 2 shorter Sn-O bonds; thus, the ligand chelates the Sn center in an asymmetric way. The synthesized compounds were also screened for antibacterial, antifungal, brine-shrimp lethality, and potato disc antitumor activity.
Keywords : Organotin IV, compounds, FT IR, multinuclear NMR, X ray structures, antibacterial, antifungal, brine shrimp lethality, antitumor activities