Synthesis of 2-Acylamino, 2-Aroylamino and Ethoxycarbonyl Imino-1,3,4-thiadiazoles as Antitumor Agents

Authors : Kemal SANCAK, Yasemin ÜNVER, Mustafa ER

Pages : 125-134

View : 20 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :2-Amino-1,3,4-thiadiazoles compounds insert ignore into journalissuearticles values(2a-e); were obtained from the reaction of thiosemi carbazide with 2-cyanomethoxyphenoxyacetonitriles insert ignore into journalissuearticles values(1);. Mono acylamino, mono aroylamino and diethoxycarbonyl imino-1,3,4-thiadiazole compounds insert ignore into journalissuearticles values(3a-e, 4a-e, 5a-c); were synthesized via the reaction of 2-amino-1,3,4-thiadiazole compounds insert ignore into journalissuearticles values(2a-e); with acetyl chloride or acetic anhydride, benzoyl chloride or benzoic anhydride and ethyl chloroformate, respectively. The in vitro antitumor activities of some selected compounds were screened and compounds 2a, 2b, 2c, 3a, 3b, 3c, 5a, 5b and 5c were found to be active.
Keywords : 1, 3, 4 Thiadiazole, acetyl chloride, benzoyl chloride, ethyl chloro formate, antitumor activity