Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic Acid Arylidenehydrazides

Authors : Aysel GÜRSOY, Banu ÜNAL

Pages : 233-246

View : 17 | Download : 12

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :3-Phenyl-6-methyl-4insert ignore into journalissuearticles values(3H);-quinazolinone-2-yl-mercaptoacetic acid hydrazide insert ignore into journalissuearticles values(3); was reacted with substituted aldehydes in absolute ethanol to obtain a new series, 3-phenyl-6-methyl-4insert ignore into journalissuearticles values(3H);-quinazolinone- 2-yl-mercaptoacetic acid arylidenehydrazides insert ignore into journalissuearticles values(4a-q);. The structures of 4a-q were elucidated by elemental analyses and from spectrometric insert ignore into journalissuearticles values(UV, IR, 1H-NMR, 13C-NMR and EIMS); data. Then 4a-q were evaluated for antibacterial, antifungal and antitubercular activities. No significant activity was observed against the selected microorganisms.
Keywords : 4 3H, Quinazolinone, arylidenehydrazide, synthesis, antimicrobial activity