Synthesis and Isolation of New Regioisomeric 4-Thiazolidinones and Their Anticonvulsant Activity

Authors : Aysel GÜRSOY, Nalan TERZİOĞLU

Pages : 247-254

View : 16 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Two regioisomer series, 2-insert ignore into journalissuearticles values(3-ethyl-4insert ignore into journalissuearticles values(3H);-quinazolinone-2- ylmercaptoacetylhydrazono);-3-alkyl/3-aryl-5-methyl-4-thiazolidinones insert ignore into journalissuearticles values(12-21); and 2-arylimino-3-insert ignore into journalissuearticles values(3-ethyl-4insert ignore into journalissuearticles values(3H);-quinazolinone-2-ylmercaptoacetylamino);- 5-methyl-4-thiazolidinones insert ignore into journalissuearticles values(22-26);, were synthesized by the cyclization of 1-insert ignore into journalissuearticles values(3-ethyl-4insert ignore into journalissuearticles values(3H);-quinazolinone-2-ylmercaptoacetyl);-4-alkyl/aryl thiosemicarbazides insert ignore into journalissuearticles values(1-11); with ethyl 2-bromopropionate in the presence of anhydrous sodium acetate in anhydrous ethanolic medium. The structures of 12-26 were confirmed by analytical and spectral data insert ignore into journalissuearticles values(IR, 1H-NMR and EIMS);. Selected members of the thiosemicarbazides and thiazolidinones were subjected to anticonvulsant activity tests by the National Institute of Neurological Disorders and Stroke MD, USA.
Keywords : 4 thiazolidinones, synthesis, separation, anticonvulsant activity