Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Authors : Saira SHAHZADI, Khadija SHAHID

Pages : 273-288

View : 17 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some new di- and tri-organotininsert ignore into journalissuearticles values(IV); derivatives of 4 different non-steroidal anti-inflammatory drugs insert ignore into journalissuearticles values(NSAIDs); with the general formulae R2SnL2 and R3SnL insert ignore into journalissuearticles values(where R = n-C8H17 and C6H5CH2); and L = 2-[insert ignore into journalissuearticles values(2,3-dimethylphenyl);amino]benzoic acid, 2-insert ignore into journalissuearticles values(2-fluoro-4-biphenyl);propionic acid, 2-insert ignore into journalissuearticles values(4-isobutylphenyl); propionic acid and 2-insert ignore into journalissuearticles values(3-benzoylphenyl);-propionic acid were synthesized. These compounds were structurally characterized by infrared and multinuclear NMR insert ignore into journalissuearticles values(1H, 13C, 119Sn); spectroscopies and mass spectrometry. The isotopic effect of tin was studied by comparison of experimental data with the simulated isotopic pattern using the Chemtool software package. These compounds were also screened against different animal and plant pathogens to study their biological activity. LD50 data show that the reported compounds have significant toxicity.
Keywords : Turk J Chem, 29, 2005, 273 288 Turk J Chem, vol 29, iss 3