Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives

Authors : Zahid SHAFIQ, Muhammad ARFAN, Nasim Hasan RAMA, Shahid HAMEED, Ghulam ABBAS, Muhammad Tahir HUSSAIN

Pages : 321-325

View : 19 | Download : 15

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :3-Dihalophenyl- and dihalobenzylisocoumarins insert ignore into journalissuearticles values(3a-c); were synthesized by condensation of homophthalic acid insert ignore into journalissuearticles values(1); with dihalobenzoyl- and dihalophenylacetyl chlorides insert ignore into journalissuearticles values(2a-c);, respectively. The alkaline hydrolysis of these isocoumarins insert ignore into journalissuearticles values(2a-c); afforded keto-acids insert ignore into journalissuearticles values(4a-c);. insert ignore into journalissuearticles values(dl);-3-insert ignore into journalissuearticles values(Dihalophenyl);- and insert ignore into journalissuearticles values(dl);-3-insert ignore into journalissuearticles values(dihalobenzyl);- 3,4-dihydroisocoumarins insert ignore into journalissuearticles values(6a-c); were obtained by reduction of keto-acids insert ignore into journalissuearticles values(4a-c); to racemic hydroxy-acids insert ignore into journalissuearticles values(5a-c); followed by cyclodehydration using acetic anhydride.
Keywords : Dihaloisocoumarins, Dihydrodihaloisocoumarins, synthesis