Secondary Metabolites of Phlomis viscosa and Their Biological Activities

Authors : İhsan ÇALIŞ, Hasan KIRMIZIBEKMEZ, John A BEUTLER, Ali A DÖNMEZ, Funda Nuray YALÇIN, Ekrem KILIÇ, Meral ÖZALP, Peter RÜEDI, Deniz TAŞDEMİR

Pages : 71-82

View : 22 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Further phytochemical studies on the aerial parts of Phlomis viscosa insert ignore into journalissuearticles values(Lamiaceae); led to the isolation of 24 compounds: 3 iridoid glycosides, 10 phenylethanoid glycosides, a megastigmane glycoside and a hydroquinone glycoside, as well as 2 lignan glucosides and 7 neolignan glucosides, 1 of which is new insert ignore into journalissuearticles values(17b);. Compound 17b was obtained as a minor component of an inseparable mixture insert ignore into journalissuearticles values(2:1); of 2 neolignan glucosides insert ignore into journalissuearticles values(17a/b);, and characterized as 3`,4-O-dimethylcedrusin 9-O-b -glucopyranoside. Full NMR data of the known 8-O-4` neolignan glucoside, erythro-1-insert ignore into journalissuearticles values(4-O-b-glucopyranosyl-3-methoxyphenyl);- 2-{2-methoxyl-4-[1-insert ignore into journalissuearticles values(E);-propene-3-ol]-phenoxyl}-propane-1,3-diol insert ignore into journalissuearticles values(18); are also reported. All isolated compounds were screened for cell growth inhibition versus 3 tumor cell lines insert ignore into journalissuearticles values(MCF7, NCI-H460, and SF-268); and several phenylethanoid glycosides were found to possess weak antitumoral activity. The phenylethanoid glycosides were also evaluated for their free radical insert ignore into journalissuearticles values(DPPH); scavenging, antibacterial and antifungal activities. The free radical insert ignore into journalissuearticles values(DPPH); scavenging activities of verbascoside insert ignore into journalissuearticles values(4);, isoacteoside insert ignore into journalissuearticles values(5);, forsythoside B insert ignore into journalissuearticles values(10);, myricoside insert ignore into journalissuearticles values(13); and samioside insert ignore into journalissuearticles values(14); were found to be comparable to that of dl-a -tocopherol. Compounds 4, 5, 10 and 14 insert ignore into journalissuearticles values(MIC: 500 m g/mL); as well as Leucosceptoside A insert ignore into journalissuearticles values(8); and 13 insert ignore into journalissuearticles values(MIC:1000 m g/mL); showed very weak activity against Gram insert ignore into journalissuearticles values(+); bacteria.
Keywords : Phlomis viscosa, iridoids, phenylethanoid glycosides, lignan glucosides, 8 O 4` oxylignan, neolignan glucosides, biological activity