An Efficient Synthesis of Substituted 4-Aryl-3-Cyano-2-Amino Thiophenes by a Stepwise Gewald Reaction

Authors : Ferhan TÜMER, Duygu EKİNCİ, Kani ZİLBEYAZ and Ümit DEMİR

Pages : 395-404

View : 23 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The title compounds were efficiently synthesised starting from aryl methyl ketones in 3 steps. Knoevenagel condensation of aryl methyl ketones with malononitrile gave the corresponding crotonitriles insert ignore into journalissuearticles values(5a-f);. Methyl groups of the crotonitriles insert ignore into journalissuearticles values(5a-f); were then efficiently brominated by refluxing and lightening the reaction media to give bromocrotonitriles insert ignore into journalissuearticles values(6a-f);. The bromocrotonitriles insert ignore into journalissuearticles values(6a-f); were finally cyclised by treatment with NaSH to give the title compounds.
Keywords : Aminothiophenes, bromocrotonitriles, substituted aminothiophenes