Synthesis and Microbiological Activity of Some Substituted N-(2-hydroxy-4-nitrophenyl)benzamides and Phenylacetamides as Possible Metabolites of Antimicrobial Active Benzoxazoles

Authors : İlkay YILDIZ ÖREN, Esin AKIŞENER, Cengiz ERTAŞ

Pages : 441-450

View : 22 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some new antimicrobial active N-insert ignore into journalissuearticles values(2-hydroxy-4-nitrophenyl);- p-substituted benzamide and phenylacetamide analogues insert ignore into journalissuearticles values(I-II); were prepared by 2-step procedures from the corresponding carboxylic acids as possible metabolites of benzoxazoles. Their antimicrobial activities were tested against 3 Gram-positive and 2 Gram-negative bacteria with the fungus Candida albicans and were also compared with several control drugs. The compounds Ia, Id, IIa, and IIe were active at a MIC value of 12.5 m g/mL against the Gram-positive microorganism Bacillus subtilis. Most of the compounds exhibited antifungal activity at a MIC value of 12.5 m g/mL against C. albicans. On the other hand, the antimicrobial activity of some amide derivatives insert ignore into journalissuearticles values(Ia, Id, IIa-c); was also compared with their cyclic analogues, benzoxazole derivatives insert ignore into journalissuearticles values(III-IV);. The compound Id significantly possessed 2 or 3 dilutions better antimicrobial activity than its heterocyclic derivative, 2-insert ignore into journalissuearticles values(p-t-butylphenyl);-5-nitrobenzoxazole, IIId, against Staphylococcus aureus, Streptococcus faecalis, Klebsiella pneumonia, and Escherichia coli.
Keywords : Antimicrobial activity, benzamide, benzoxazole, phenylacetamide