Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole

Authors : Tijen ÖNKOL, Bilge ÇAKIR, M Fethi ŞAHİN

Pages : 461-468

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Ten 2-[insert ignore into journalissuearticles values(2-oxobenzothiazolin-3-yl);methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and 1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[insert ignore into journalissuearticles values(2-oxobenzothiazolin-3-yl);methyl]-5-aminomethyl-1,3,4-thiadiazole insert ignore into journalissuearticles values(5a); was found to be significantly more active than the others and the standards in all the tests.
Keywords : 2 Oxobenzothiazoline, 1, 3, 4 thiadiazole, antinociceptive activity