Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide

Authors : Bashir AHMAD, Shumaila BASHIR, Shamsun NISA, M B HUGLIN

Pages : 279-286

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone insert ignore into journalissuearticles values(VP); and 2-hydroxyethyl methacrylate insert ignore into journalissuearticles values(HEMA); were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.
Keywords : N vinyl 2 pyrrolidone, 2 hydroxyethyl methacrylate, Hydrogels, Drug release