Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones

Authors : Deniz S DOĞRUER, M Fethi ŞAHİN

Pages : 727-738

View : 17 | Download : 11

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new series of 2-insert ignore into journalissuearticles values(6-oxo-3,5-diphenyl-6H-pyridazin-1-yl);- acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl);-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone--induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.
Keywords : 6 Oxo 3, 5 diphenylpyridazine, synthesis, spectral analysis, analgesic, anti inflammatory