DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases

Authors : Murat KIZIL

Pages : 539-544

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copperinsert ignore into journalissuearticles values(II); chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.
Keywords : Aryl radicals, diazonium salts, DNA cleavage