Synthesis of New Antimicrobial Agents; Amide Derivatives of Pyranones and Pyridinones

Authors : Mutlu Dilsiz AYTEMİR

Pages : 445-452

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, 4insert ignore into journalissuearticles values(1H);-pyridinones with an amide function in Position 2 of the pyridinone ring showed antimicrobial activity. The synthesis and the biological properties of some novel amide derivatives of pyran-4insert ignore into journalissuearticles values(1H);-one and 4insert ignore into journalissuearticles values(1H);-pyridinone have been reported. Amide derivatives of pyran-4insert ignore into journalissuearticles values(1H);-one and 4insert ignore into journalissuearticles values(1H);-pyridinone were prepared using two different methods. Antimicrobial activities were determined as MIC values using the microdilution broth method against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa and the fungi Candida albicans, Candida krusei and Candida parapsilosis. Compounds 6 and 9 exhibited the best inhibitor activity against S. aureus.
Keywords : Pyran 4 1H, one, 4 1H, pyridinone, antibacterial activity, antifungal agents