Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge

Authors : Deniz TAŞDEMİR

Pages : 273-279

View : 11 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Two bisabolane type sesquiterpene phenols, insert ignore into journalissuearticles values(+);-curcuphenol insert ignore into journalissuearticles values(1); and insert ignore into journalissuearticles values(+);-curcudiol insert ignore into journalissuearticles values(2);, were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol insert ignore into journalissuearticles values(3); and phenethylamine insert ignore into journalissuearticles values(4);. The structures of the metabolites were established on the basis of spectral evidence insert ignore into journalissuearticles values(1D- and 2D NMR, [a]D, EIMS);. insert ignore into journalissuearticles values(+);-Curcuphenol insert ignore into journalissuearticles values(1); showed cytotoxicity, which is indicative of a p53 independent mechanism.
Keywords : Marine sponge, Didiscus, , curcuphenol, , curcudiol, b sitosterol, phenethylamine, HCT 116