An Efficient Synthesis of Alnustone, a Naturally Occurring Compound

Authors : Süleyman GÖKSU, Hülya ÇELİK, Hasan SEÇEN

Pages : 31-34

View : 17 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Alnustone, 4insert ignore into journalissuearticles values(E);,6insert ignore into journalissuearticles values(E);-1,7-diphenyl-hepta-4,6-dien-3-one, was synthesized starting from benzaldehyde in three steps with an overall yield of 57%. The condensation of benzaldehyde with acetone gave benzalacetone. The Pd-C catalyzed hydrogenation of benzalacetone afforded benzylacetone. The in situ enamination of benzylacetone with pyrrolidine and acetic acid followed by cinnamaldehyde treatment gave alnustone.
Keywords : alnustone, 4 E, 6 E, 1, 7 diphenyl hepta 4, 6 dien 3 one, diarylheptanoid, benzaldehyde, benzalacetone, benzylacetone, cinnamaldehyde