Spectrophotometric Determination of Mexiletine Hydrochloride in Capsules Using Bromothymol Blue

Authors : Zeynep AYDOĞMUŞ, S Müge ÇETİN, Sedat TOSUNOĞLU

Pages : 839-842

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08--10.8 m g.ml-1 at lmax = 408 nm insert ignore into journalissuearticles values(r = 0.9999);. The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia method.
Keywords : Spectrophotometry, Mexiletine hydrochloride, Bromothymol blue, Ion pair