Photochemically-Induced Fluorescence Properties and Determination of Flufenamic Acid, a Non-Steroidal Anti-Inflammatory Drug, in Urine and Pharmaceutical Preparation

Authors : Leila Bettaieb And Jeanjacques AARON

Pages : 165-171

View : 13 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The photochemically-induced fluorescence insert ignore into journalissuearticles values(PIF); properties of flufenamic acid insert ignore into journalissuearticles values(FF);, a non-steroidal anti-inflammatory drug insert ignore into journalissuearticles values(NSAID); were investigated in acidic insert ignore into journalissuearticles values(pH 1.0); aqueous solutions at room temperature. An optimization procedure, including the effects of UV irradiation time, pH and solvent, was established for the determination of FF. A linear logarithmic calibration plot was obtained over a wide concentration range of four orders of magnitude. A low limit of detection of 0.14 ng/mL was found. The relative standard deviation insert ignore into journalissuearticles values(RSD); was 6.6% . The PIF method was applied to the quantitative analysis of FF in urine and in a pharmaceutical preparation with satisfactory recovery values.
Keywords : Photochemically induced fluorescence, flufenamic acid, urine analysis, pharmaceutical preparation