Ion-Selective Membrane Electrode for the Determination of a Novel Phenylpiperazine Antidepressant, Nefazodone

Authors : Arzum ERDEM, Dilşat ÖZKAN, Kağan KERMAN, Burcu MERİÇ

Pages : 353-360

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The construction and performance characteristics of ion-selective membrane electrodes for a newly found phenylpiperazine antidepressant, Nefazodone insert ignore into journalissuearticles values(NFN);, based on its ion-pair complexes with phosphotungstate insert ignore into journalissuearticles values(PT);, tetraphenylborate insert ignore into journalissuearticles values(TPB);, tungstosilicate insert ignore into journalissuearticles values(TS); and reineckate insert ignore into journalissuearticles values(RN); in a polyinsert ignore into journalissuearticles values(vinyl chloride); insert ignore into journalissuearticles values(PVC); matrix are described. The best ion-selective electrode for determination of NFN contains NFN-PT as the active material. This electrode exhibits a Nernstian response insert ignore into journalissuearticles values(62.6 ± 0.4 mV per decade); in the range 1.5 x 10-5 to 1.0 x 10-2 M NFN.HCl in solutions. The selectivity of this electrode to NFN in the presence of a number of sugar molecules, cations and drugs is reported. The potentiometric standard addition method and the argentometric titration method are used to determine the NFN amount in pure solution.
Keywords : Turk J Chem, 24, 2000, 353 360 Turk J Chem, vol 24, iss 4