Preparation of Optically Active Amino Acid Derivatives of Some Methylated 5-Amino-Azaheterocycles

Authors : Mashooda HASAN, Farzana SHAHEEN, Uzma YUNUS and Shazia

Pages : 165-176

View : 13 | Download : 13

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The present paper describes the reduction of 1-methyl-5-nitro-benzimidazoles insert ignore into journalissuearticles values({\bf 1A, 2A}); and 1,3-dimethyl-2H-5-nitro-benzimidazol-2-one insert ignore into journalissuearticles values({\bf 3}); to 5-aminobenzimidazoles insert ignore into journalissuearticles values({\bf 4A, 5A}); and 1,3-dimethyl-2H-5-amino-benzimidazol-2-one insert ignore into journalissuearticles values({\bf 6}); respectively with hydrazine hydrate in absolute ethanol in the presence of graphite. Compounds {\bf 5A} and {\bf 6} were converted to 2-ethyl-5-insert ignore into journalissuearticles values(phthaloyl-L-phenylalanyl);amino-1-methylbenzimidazole insert ignore into journalissuearticles values({\bf 7}); and 1,3-dimethyl-5-insert ignore into journalissuearticles values(phthaloyl-L-phenylalanyl);aminobenzimidazol-2-one insert ignore into journalissuearticles values({\bf 8});. Characterization of the synthesized compounds was done with the help of mass spectrometry and 1H NMR spectroscopic studies. Optical activity of the amino acid derivatives {\bf 7} and {\bf 8} was also recorded.
Keywords : Turk J Chem, 24, 2000, 165 176 Turk J Chem, vol 24, iss 2