Conformational Analysis of Linear Peptide (Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7NH2 )

Authors : L DEMİR, A KARABULUT, G BUDAK, Y ŞAHİN

Pages : 257-262

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Conformational energy-minimization of the Sea Anemone and Sea Pansy neuropeptide Pol-RFamide insert ignore into journalissuearticles values(Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7-NH2); was carried out by molecular mechanics insert ignore into journalissuearticles values(MM);. The linkage bonds were characterized by the torsion angles q, y and w and the side groups were characterized by the torsion angles c1, c2, c3\ldots The energy-map for each monopeptide of the Pol-RFamide I was drawn in the range of -180° to 180° with increments of 20°. Conformation facilities for monopeptides were determined from these maps. These results were used in the analysis of the dipeptide insert ignore into journalissuearticles values(Glu1-Leu2);. Then, the insert ignore into journalissuearticles values(Glu1-Leu2-Leu3); tripeptide was examined using the calculated results for the dipeptide. Conformational analysis of the insert ignore into journalissuearticles values(Glu1-Leu2-Leu3-Gly4); tetrapeptide was performed using the low-energy values for the tripeptide. The space structure of the insert ignore into journalissuearticles values(Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7-NH2); neuropeptide was found as a result of minimization of energies by rotating the tetrapeptide insert ignore into journalissuearticles values(Glu1-Leu2-Leu3-Gly4); and the dipeptide insert ignore into journalissuearticles values(Arg6-Phe7-NH2); about the monopeptide insert ignore into journalissuearticles values(Gly5);.
Keywords : Turk J Chem, 23, 1999, 257 262 Turk J Chem, vol 23, iss 3