Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H -benzimidazoles

Authors : Ayşe Selen ALP, Gülgün KILCIGİL, Elçin Deniz ÖZDAMAR, Tülay ÇOBAN, Binay EKE

Pages : 42-53

Doi:10.3906/kim-1403-44

View : 21 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some novel 2-insert ignore into journalissuearticles values(substitutedbenzylthio);-5-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(4-substitutedphenyl);-1H-benzo[d]imidazol-1-yl);methyl);-1,3,4-oxadiazoles insert ignore into journalissuearticles values(5--12); and 2-insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(4-chlorophenyl);-1H-benzo[d]imidazol-1-yl);-N`-insert ignore into journalissuearticles values(arylmethylene);acetohydrazide derivatives insert ignore into journalissuearticles values(13--22); were prepared and their in vitro antioxidant properties were investigated by determination of rat liver microsomal NADPH-dependent inhibition of lipid peroxidation insert ignore into journalissuearticles values(LP); levels and microsomal ethoxyresorufin O-deethylase insert ignore into journalissuearticles values(EROD); activity. Compound 18 was found to be the most active compound with 100% inhibition on LP level and 92% inhibition on EROD. Compounds 4b, 17, and 19 showed the strongest inhibitory effect insert ignore into journalissuearticles values(97%); on EROD. The free radical scavenging capacities of the compounds were also tested in vitro determining the interaction of the stable free radical 2,2,diphenyl-1-picrylhydrazyl insert ignore into journalissuearticles values(DPPH);, and compounds 4a and 4b exhibited good antioxidant activities.
Keywords : Antioxidant, lipid peroxidation, benzimidazole, oxadiazole, imine