Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Authors : Leyla YURTTAŞ, Yusuf ÖZKAY, Fatih DEMİRCİ, Gamze GÖGER, Şafak Ulusoylar YILDIRIM, Usama ABU MOHSEN, Ömer ÖZTÜRK, Zafer Asım KAPLANCIKLI

Pages : 815-824

Doi:10.3906/kim-1312-62

View : 24 | Download : 15

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds insert ignore into journalissuearticles values(6a--j); were confirmed by spectral data insert ignore into journalissuearticles values(IR, 1H NMR, 13C NMR, and MS); and elemental analysis. The anticandidal activity of the compounds was determined insert ignore into journalissuearticles values(6a--j); using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT insert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(4,5-dimethylthiazol-2-yl);-2,5-diphenyltetrazolium bromide); assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 m g/mL.
Keywords : Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity