Synthesis of novel imidazo[1,2-a]pyridines and evaluation of their antifungal activities

Authors : Füsun GÖKTAŞ, Nesrin CESUR, Dilek ŞATANA, Meltem UZUN

Pages : 581-591

Doi:10.3906/kim-1307-14

View : 22 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :New 2-insert ignore into journalissuearticles values(imidazo[1,2-a]pyridin-2-ylcarbonyl);-N-substituted hydrazinecarbothioamides insert ignore into journalissuearticles values(4a--j);, N`-insert ignore into journalissuearticles values(3-substituted-4-oxo-1,3-thiazolidin-2-ylidene);imidazo[1,2-a]pyridine-2-carbohydrazides insert ignore into journalissuearticles values(5a--f);, and N-insert ignore into journalissuearticles values(nonsubstituted/4-substituted phenyl);-5-insert ignore into journalissuearticles values(imidazo[1,2-a]pyridine-2-yl);-1,3,4-oxadiazole-2-amines insert ignore into journalissuearticles values(6a--d); were synthesized from imidazo[1,2-a]pyridine-2-carbohydrazide insert ignore into journalissuearticles values(3); and evaluated for antifungal activity against Microsporum gypseum NCPF 580, M. canis, Trichophyton tonsurans NCPF 245, T. rubrum, Candida albicans ATCC 10231, and C. parapsilosis ATCC 22019 using amphotericin B as the standard. The chemical structures of the compounds were confirmed by elemental analysis, IR, 1H NMR, 13C NMR, HMBC insert ignore into journalissuearticles values(13C, 1H);, and mass spectra. Most of the tested compounds showed moderate antifungal activity. Hydrazinecarbothioamide derivatives 4h and 4f exhibited the highest activity against M. canis insert ignore into journalissuearticles values(MIC: 2 m g mL-1 and 4 m g mL-1, respectively);.
Keywords : Imidazo 1, 2 a pyridine, hydrazinecarbothioamide, 4 oxo 1, 3 thiazolidine, 1, 3, 4 oxadiazole, antifungal activity