Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

Authors : MEHDI RIMAZ, PARIA POURHOSSEIN, BEHZAD KHALILI

Pages : 244-0

Doi:10.3906/kim-1408-32

View : 17 | Download : 14

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7insert ignore into journalissuearticles values(6H,8H);-diones and 3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazin-5insert ignore into journalissuearticles values(6H);-ones were efficiently synthesized via a regiospecific one-pot reaction of N-methylbarbituric acid and N-ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in the presence of hydrazine dihydrochloride in ethanol at 50 °C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAO_{B} inhibitors.
Keywords : Pyrimido 4, 5 c pyridazine, regiospecific, arylglyoxal, N methylbarbituric acid, N ethyl 2 thiobarbituric acid