Contribution of heterobifunctional ligands to transition metal-catalysed C--C coupling reactions

Authors : Agnes LABANDE, Eric DEYDIER, Eric MANOURY, Jeanclaude DARAN, Catherine AUDIN, Rinaldo POLI

Pages : 1158-1170

View : 19 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this account the authors` latest results in C--C coupling catalysis are reviewed. First, an efficient catalytic system for the Kumada--Tamao--Corriu coupling reaction based on NHC-phosphine insert ignore into journalissuearticles values(NHC = N-heterocyclic carbene); nickel complexes is presented. Then the use of palladium complexes of chiral ferrocenyl NHC-phosphines in the asymmetric Suzuki--Miyaura coupling reaction is reported. High catalytic activities and moderate enantioselectivities insert ignore into journalissuearticles values(ee up to 46{\%}); were obtained. Chiral ferrocenyl phosphine--ethers were also tested in the asymmetric Suzuki--Miyaura reaction yielding good activities and moderate enantioselectivities insert ignore into journalissuearticles values(ee up to 37{\%});. Finally, the original synthesis of a ferrocenyl rhodiuminsert ignore into journalissuearticles values(III); complex and its successful use as catalyst for a C--C coupling reaction via C--H activation of 2-phenylpyridine is presented.
Keywords : Chiral ferrocenyl ligands, NHC ligands, P, O ligands, palladium, Kumada Tamao Corriu reaction, Suzuki Miyaura cross coupling, asymmetric catalysis