Palladium-catalyzed ligand-free and efficient Suzuki--Miyaura reaction of $N$-methyliminodiacetic acid boronates in water

Authors : Chun LIU, Xinmin LI, Xinnan WANG, Jieshan QIU

Pages : 1208-1215

View : 20 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A green and efficient protocol has been developed for the Pdinsert ignore into journalissuearticles values(OAc);$_{2}$-catalyzed ligand-free Suzuki--Miyaura reaction of $N$-methyliminodiacetic acid insert ignore into journalissuearticles values(MIDA); boronates in water. In the presence of Pdinsert ignore into journalissuearticles values(OAc);$_{2}$ as a catalyst and insert ignore into journalissuearticles values($i$-Pr);$_{2}$NH as a base, the cross-coupling reactions of aryl bromides with aryl MIDA boronates proceeded smoothly in water without any surfactant, and various functional groups were tolerated under the optimized conditions.
Keywords : Palladium, ligand free, Suzuki Miyaura reaction, N methyliminodiacetic acid boronates, water