Synthesis of new thiol-derivatized aminophosphines and their catalytic activities in C--C coupling reactions

Authors : Nermin BİRİCİK, Nermin MERİÇ, Cezmi KAYAN, Zeynep ÖZGEN, Sevil Şeker AZİZOĞLU, Bahattin GÜMGÜM

Pages : 1257-1264

View : 20 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of new aminophosphines [Ph$_{2}$PHN-C$_{6}$H$_{4}$-R, where R = $o$-SH insert ignore into journalissuearticles values(\textbf{4a});, $m$-SH insert ignore into journalissuearticles values(\textbf{4b); or }$p$-SH insert ignore into journalissuearticles values(\textbf{4c});] were readily synthesized from cheap starting materials by the phosphorylation reaction of $o$, $m$, and $p$-aminothiophenols with Ph$_{2}$PCl in the presence of triethyl amine. The new compounds were characterized by NMR and IR spectroscopy and microanalysis. In addition, aminophosphine ligands--palladium systems were investigated as precatalysts in C--C coupling reactions. Compounds \textbf{4b} and \textbf{4c }were proved to be excellent catalysts for Suzuki and Heck cross-coupling reactions.
Keywords : Aminophosphine, synthesis, catalysis, palladium, Suzuki Heck