Synthetic protocols on 6$H$-benzo[$c$]chromen-6-ones: a review

Authors : OFENTSE MAZIMBA

Pages : 1-27

View : 14 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :6$H$-Benzo[$c$]chromen-6-ones serve as core structures of secondary metabolites and are of considerable pharmacological importance. Natural sources produce limited quantities, hence the need for synthetic procedures for 6$H$-benzo[$c$]chromen-6-ones, which are herein reviewed. The literature describes protocols such as the Suzuki coupling reactions for the synthesis of biaryl, which then undergoes lactonization, reactions of 3-formylcoumarin insert ignore into journalissuearticles values(chromenones); with 1,3-bisinsert ignore into journalissuearticles values(silylenol ethers);, radical mediated cyclization of arylbenzoates, metal or base catalyzed cyclization of phenyl-2-halobenzoates and 2-halobenzyloxyphenols, and benzoic acid coupling with benzoquinone using electrophilic metal-based catalyst. The efficient and simple procedures are those involving the reactions of Michael acceptor insert ignore into journalissuearticles values(chromenones and chalcones); with 1,3- and 1,5-dicarbonyl compounds.
Keywords : 6 H Benzo c chromen 6 ones, benzopyranone, biaryls, Suzuki coupling, Michael addition, lactonization