Voltammetric determination of famotidine on a disposable pencil graphite electrode

Authors : IULIA GABRIELA DAVID, DANA ELENA POPA, ANDREEAALEXANDRA CALIN, MIHAELA BULEANDRA, EMILIAELENA IORGULESCU

Pages : 125-135

View : 14 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The present paper describes the use of a disposable pencil graphite electrode insert ignore into journalissuearticles values(PGE); for the voltammetric determination of famotidine. Cyclic voltammetric studies using different supporting electrolytes emphasized an irreversible oxidation of famotidine on the PGE. The electrode process is diffusion-controlled and pH-dependent. Differential pulse voltammetry insert ignore into journalissuearticles values(DPV); in phosphate buffer solution of pH 6.81 was employed for famotidine`s quantitative determination. The anodic peak current of famotidine varies linearly with the analyte concentration in the range 4.72 $\times $ 10$^{-7}$--4.95 $\times $ 10$^{-4}$ M. Detection and quantification limits were 1.51 $\times $ 10$^{-7}$ M and 5.04 $\times $ 10$^{-7}$ M famotidine, respectively. The developed DPV method using the inexpensive, disposable PGE was successfully applied to the simple and rapid determination of famotidine from pharmaceuticals.
Keywords : Famotidine, pencil graphite electrode, voltammetry, pharmaceuticals