Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction

Authors : RABİA DELİKUŞ, EMİNE ÇAKIR, NADİR DEMİREL, METİN BALCI, BETÜL KARATAŞ

Pages : 248-261

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetric Henry reaction. Various aromatic aldehydes were converted into chiral $\beta $-nitro alcohols with high yields and moderate to acceptable enantioselectivities under the optimized reaction conditions.
Keywords : Asymmetric synthesis, Henry reaction, chiral bisoxazolines, nitroaldol, copper