Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives

Authors : Kamal M DAWOOD, Eman A RAGAB, Korany A ALI

Pages : 277-282

View : 12 | Download : 12

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :1-insert ignore into journalissuearticles values(Benzothiazol-2-yl);-3-phenylthiourea\textbf{ 2} was prepared and treated with hydrazonoyl chlorides \textbf{3a}--\textbf{e }to yield the corresponding 5-insert ignore into journalissuearticles values(benzothiazol-2-ylimino);-1,3,4-thiadiazole derivatives \textbf{6a}--\textbf{e}, respectively. Reaction of the thiourea derivative \textbf{2} with ethyl 2-chloro-3-oxobutanoate \textbf{9} afforded the corresponding 2-insert ignore into journalissuearticles values(benzothiazol-2-ylimino);thiazole-5-carboxylate derivative \textbf{11}. The newly synthesized heterocyclic derivatives were confirmed from their elemental and spectral analyses.
Keywords : Benzothiazole, thiazole, thiadiazole, thiourea, hydrazonoyl chlorides