New antimicrobial biscembrane hydrocarbon and cembranoid diterpenes from the soft coral Sarcophyton trocheliophorum

Authors : MUHAMMAD ZUBAIR, WALIED ALARIF, KHALID ALFOOTY, MOHAMED PH, MAGDA ALI, SALIM BASAIF, SULTAN ALLIHAIBI, SEIFELDIN AYYAD

Pages : 385-392

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new tetracyclic biscembrane hydrocarbon, trocheliane insert ignore into journalissuearticles values(1);, along with two new cembranoid diterpenes, sarcotrocheldiol A insert ignore into journalissuearticles values(2); and B insert ignore into journalissuearticles values(3);, and the known diterpene cembrene-C insert ignore into journalissuearticles values(4);, were isolated from the Red Sea soft coral Sarcophyton trocheliophorum. The structures and relative stereochemistry of the compounds were elucidated by interpretation of MS, 1 D NMR, and 2 D NMR experiments. The sensitivity of some pathogenic bacteria used as test organisms to the new compounds 1-3 was determined. 1 showed appreciable antimicrobial activity with the diameter of inhibition zones ranging from 11 to 18 mm. 1 was active against the two multidrug resistant bacteria Acinetobacter baumannii and Staphylococcus aureus. Minimal inhibitory concentrations insert ignore into journalissuearticles values(MICs); of compound 1 were recorded for all the tested bacteria using the fluorescein diacetate method and the recorded MIC values ranged from 4 to 6 $\mu $M.
Keywords : Soft coral, biscembranes, diterpenoids, antibacterial activity